실험적구루병에서 백서 치아조직 변화에 관한 현미경학적 연구
A MICROSCOPIC STUDY OF THE EFFECTS OF EXPERIMENTAL RICKETS ON THE OENTAL STRUCTURE OF RATS
유태형, 이종갑,
소속 상세정보
유태형 ( ) - 연세대학교
이종갑 ( ) - 연세대학교 치과대학 소아치과학
KMID : 0358919800070010075
Abstract
40마리의 백서에 high calcium, low phosphorus, vitamin D deficient인 rachitogenic diet를
1∼56일 동안 투여하고 치아와 치아 주위조직에 나타나는 변화를 정상사료를 투여한 24마리
의 대조군과 비교한 결과 다음과 같은 성적을 얻었다.
1. 범랑질의 형성과 석회화는 정상이었으며 형성부전의 형태학적 변화를 보이지 않았다.
2. 실험군에서 상아질의 형성과 석회화는 지연되어 상아질에 대한 Predentin의 비율이 대
조군에 비하여 현저히 증가되었다.
3. 새로 형성되는 상아짙은 대단히 globular 하며 predentin과 석회화된 상아질의 경계가
불규칙 하였으며 특히 기저부에서는 상아질이 두터우면서 불규칙적인 파상으로 관찰되었다.
4. 백아질의 기질은 형성되나 석회화가 지연되어 cementoid tissue가 증가되었다.
5. 치조골도 기질은 형성되나 석회화가 지연되어 육주골이 유골조직으로 구성되어 두꺼워
졌다.
#초록#
Rickets is not the deposite of minerals in the skeletal tissue and the retardation of
skeletal growth in growing in growing animals
This study was undertaken to investigate the histologic effects of experimental rickets
en the dental structure of the albino rats, and to show the relationship between the
histological effects and the pulpal disease which induced premature loss of the primary
teeth.
This study was based on material obtained from 40 white rats that were placed on a
rachitogenic diet for a period 1 to 56 days after weaning (at 24 days).
In addition, a study was made of 25 litter mates,24 to 80 days, that were fed a normal
diet,
The following results were obtained ;
1. Enamel formation and calcification showed no significant changes and no hypoplasia.
2. Dentin formation and calcification was retarded and disturbed. In the experimental
group, predentin/calcified dentin was remarkablly increased
3. Newly formed dentin showed interglobular texture (less homogenous calcificaton) and
the predentil was significantly wider and thicker, and there was an irregular wave in
the basal portion of the rat's incisors.
4. In cementum, Matrix formed at almost a normal rate but calcification was defective.
So cementoid tissue was increasesd.
5. The formation of the alveolar bone was at almost a normal rate but calcification
was retarded.
The trabecular bone was filled with osteoid tissue and thicker than in normal groups.
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